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Summary Metabolic changes resulting from obesity, insulin insensitivity, and imbalances in hormones such as adiponectin, leptin, resistin, apelin and visfatin, which are derived from white adipose tissue-derived hormone, are directly linked to both colon cancer (CC) and inflammatory bowel diseases increasing tissue-derived risk. We conducted this study to evaluate the relationship between the circulating concentrations of adiponectin, leptin, resistin, apelin and visfatin and colon adenoma and CC. Our study included 90 participants aged >18 years who were divided into three groups: colon cancer, adenoma and control. The serum concentrations of the investigated adipohormones were measured with ELISA in 30 patients with colon adenoma, 30 with CC and 30 controls with no colon pathology. Demographic, anthropometric, metabolic and hormonal parameters were also recorded. The group means were compared by using one-way analysis of variance (ANOVA). Dual comparisons between groups were analyzed with the Tukey test. Pearson correlation coefficient was used to determine the relation between continuous variables. Adiponectin and leptin levels in patients with adenomas (p<0.000; p<0.000, respectively) and CC (p<0.000; p<0.000, respectively) were lower than in controls. Apelin level in patients with CC (p<0.000; p<0.000, respectively) was lower than in patients with adenomas and in controls. Resistin and visfatin levels in patients with CC (p<0.000; p<0.000, respectively) were higher than in patients with adenomas and in controls. Kratak sadrzaj Metaboli~ke promene koje su posledica gojaznosti, neosetljivosti na insulin i poreme}aja ravnote`e hormona kao {to su adiponektin, leptin, rezistin, apelin i visfatin, koji poti~u od hormona iz belog adipoznog tkiva, direktno su povezane sa rakom debelog creva (CC) kao i sa inflamatornim bolestima creva koje pove}avaju rizik od raka debelog creva. Spro - veli smo ovu studiju kako bismo istra`ili odnos izme|u cirku - li{u}ih koncentracija adiponektina, leptina, rezistina, apelina i visfatina, i adenoma i raka debelog creva. Na{a studija obuhvatila je 90 u~esnika starih >18 godina koji su podeljeni u tri grupe: rak debelog creva, adenom i kontrolna grupa. Koncentracije ispitivanih adipohormona u serumu izmerene su pomo}u ELISA kod 30 pacijenata sa adenomom debelog creva, 30 sa rakom debelog creva i 30 kontrolnih subjekata bez patolo{kih promena na debelom crevu. Demografski, antropometrijski, metaboli~ki i hormonski parametri tako|e su bele`eni. Proseci grupa upore|eni su pomo}u analize ANOVA. Dvostruka pore|enja izme|u grupa izvedena su pomo}u Tukijevog testa. Za odre|ivanje odnosa izme|u kontinuiranih varijabli upotrebljen je Pirsonov koeficijent korelacije. Nivoi adiponektina i leptina kod pacijenata sa adenomima (p<0,000; p<0,000) i CC (p<0,000; p<0,000) bili su ni`i nego kod kontrolnih subjekata. Nivo apelina kod pacijenata sa CC (p<0,000) bio je ni`i nego kod pacijenata sa adenomima i kontrolnih subjekata. Nivoi rezistina i visfatina kod pacijenata sa CC (p<0,000; p<0,000) bili su vi{i nego kod pacijenata sa adenomima i kontrolnih subjekata.

THE ROLE OF ADIPOCYTOKINES IN COLON CANCER AND ADENOMAS / ULOGA ADIPOCITOKINA U KANCERU I ADENOMIMA DEBELOG CREVA