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Periodontal diseases are the most common diseases in veterinary medicine. The first clinical finding is chewing difficulty, saliva flow and bad oral odor. It further develops into plaque and tartar formation, gingival inflammation and hemorrhagic appearance of the gingiva, periodontal pockets formation, alveolar bone resorption and tooth loss. In this study an evaluation has been made to determine which degree reflects on the parameters of systemic inflammatory reaction with special attention to IL-6 (Interleukine-6), CRP (C-reactive protein), osteopontin, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GPx) and Ig (Immunglobulins = Total protein – Albumin) and hematological parameters in dogs with periodontitis. Two groups have been defined in this study. The first group included 10 healthy and owned dogs as a control group. The second group consisted of 10 owned dogs with moderate-severe periodontitis. The difference between monocyte (p <0.001) and neutrophil (p <0.05) counts was found to be significant. In addition, the difference between SOD, MDA, glutathione peroxidase, CRP, IL-6 measurements in group 1 and group 2 was significant. (p <0.001). The level of osteopontin in moderate-severe periodontitis cases was found significantly higher than the level measured in the healthy group. Measured values in the moderate-severe periodontitis cases are higher than the healthy group in terms of CRP, IL-6, and osteopontin levels. Increasing severity of periodontitis was associated with changes in oxidative stress parameters: increased MDA, decreased SOD and glutathione peroxidase levels. These differences provide important information about the evaluation of the cellular responses. There is a need for continued research into the systemic impact of periodontal disease.

Evaluation of Systemic Inflammation Parameters in Dogs with Periodontitis