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Periodontitis is an inflammatory disease that occurs in tooth-supporting tissues with a high prevalence. Porphyromonas gingivalis is the primary bacteria that cause periodontitis. In the inflammatory process, mononuclear cell, such as macrophages and lymphocytes, infiltrate. Macrophages and lymphocytes play an essential role in the body’s defence against pathogens during inflammation. However, excessively activated macrophages and lymphocytes can cause tissue damage. One of the natural ingredients that can act as an antiinflammatory is Robusta coffee. This study was aimed to analyse the effect of brewed Robusta coffee on the number of macrophage and lymphocyte cells in the chronic periodontitis rat model. Methods: This research was a laboratory experiment towards 20 rats, which were randomly divided into five groups: the control group (K); group of mice induced by Porphyromonas gingivalis (P5-A); group of mice induced by Porphyromonas gingivalis and administered with brewed robusta coffee (P5-B), euthanised on the 19th day 19; group of mice induced by Porphy-romonas gingivalis (P7-A); group of mice induced by Porphyromonas gingivalis and administered with brewed robusta cof-fee (P7-B), euthanised on the 21st day. Brewed robusta coffee was administered for as much as 3.6 ml during 14 days. Tis-sue processing and HE staining were performed on the mandibular preparations— calculation of macrophages and lympho-cytes in the area around the lower M1 buccal alveolar. The results were then analysed with one-way ANOVA. Results: There was a significant difference in the number of macrophages and lymphocytes between the control and the treatment group (p<0.05). However, there was no significant difference (p>0.05) found in the number of lymphocytes between all treatment groups (P5-A, P5-B, P7-A, and P7B). Conclusion: Brewed Robusta coffee can reduce the number of macrophage and lymphocyte cells in the chronic periodontitis rat model.

padjadjaran journal of dental researchers and students

&lt;p&gt;Efek pemberian seduhan kopi robusta (Coffea canephora) terhadap jumlah sel makrofag dan limfosit pada model tikus periodontitis kronis&lt;/p&gt;&lt;p&gt;The effect of brewed robusta coffee (Coffea canephora) on macrophage and lymphocyte cells in rat model of chronic periodontitis&lt;p&gt;