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Nechuvstvitel'nye k antibiotikam shtammy Pseudomonas aeruginosa predstavlyayut soboj global'nuyu problemu v zdravoohranenii. Issledovanie mekhanizmov vozniknoveniya rezistentnosti lezhit v osnove razrabotki sposobov bor'by s P. aeruginosa. Cel'yu raboty bylo issledovat' vozniknovenie kross-rezistentnosti u P. aeruginosa v processe adaptacii k populyarnomu antibiotiku meropenemu. Ob"ektami issledovaniya byli obrazcy P. aeruginosa, poluchennye pri roste referentnogo shtamma P. aeruginosa ATCC 27853 na srede s vozrastayushchej koncentraciej meropenema. CHuvstvitel'nost' izolyatov k karbapenemam i kolistinu opredelyali pri pomoshchi razvedeniya v agare, chuvstvitel'nost' k kolistinu ocenivali metodom serijnyh razvedenij. Bylo polucheno 93 izolyata P. aeruginosa, dva iz kotoryh imeli snizhennuyu chuvstvitel'nost' odnovremenno k karbapenemam (meropenem, imipenem) i kolistinu. Genomy izolyatov sekvenirovali na polnogenomnom sekvenatore MGISEQ-2000; obnaruzheny missens-mutacii v genah oprD i mexD i nonsens-mutaciya v phoQ. Poluchnnye rezul'taty pokazyvayut, chto pri vozdejstvii meropenema na shtammy P. aeruginosa mozhet razvivat'sya kross-rezistentnost' k kolistinu — preparatu rezerva dlya lecheniya sinegnojnoj infekcii.

Meropenem-inducirovannoe snizhenie chuvstvitel'nosti k kolistinu u Pseudomonas aeruginosa ATCC 27853