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Izuchenie vliyaniya regulyatornyh peptidov na razvitie stress-inducirovannyh sdvigov v organizme imeet vazhnoe fundamental'noe i prikladnoe znachenie. V nastoyashchee vremya v medicine ispol'zuyut celyj ryad nejrotropnyh preparatov peptidnoj prirody, okazyvayushchih vliyanie na razvitie stressornoj reakcii, a takzhe vedut issledovanie novyh perspektivnyh molekul. Cel'yu raboty bylo izuchit' effekty sinteticheskogo analoga adrenokortikotropnogo gormona (AKTG) AKTG(6-9)-Pro-Gly-Pro v dozah 5, 50 i 500 mkg/kg na processy svobodnoradikal'nogo okisleniya u krys Vistar v usloviyah dvuhnedel'nogo hronicheskogo immobilizacionnogo stressa (HIS). Urovni 8-okso-2'-dezoksiguanozina (8-OHdG) i superoksiddismutazy 3 (SOD3) v syvorotke krovi ocenivali s primeneniem immunofermentnogo analiza, a urovni produktov, reagiruyushchih s tiobarbiturovoj kislotoj (TBK-RP), ocenivali fluorimetricheskim metodom. HIS privodil k znachimomu povysheniyu urovnya 8-OHdG na 18,4% (p = 0,01) i snizheniyu SOD3 na 14,3% (p = 0,01), no ne vliyal na uroven' TBK-RP. Primenenie AKTG(6-9)-Pro-Gly-Pro v dozah 5 i 50 mkg/kg znachimo snizhalo soderzhanie 8-OHdG na 19,8% (p = 0,03) i 30% (p = 0,001) sootvetstvenno. Takim obrazom, ustanovleno, chto HIS privodit k razvitiyu okislitel'nogo stressa u zhivotnyh. Vvedenie AKTG(6-9)-Pro-Gly-Pro v dozah 5 i 50 mkg/kg okazyvaet ingibiruyushchee vliyanie na stress-inducirovannye processy svobodnoradikal'nogo okisleniya.

Vliyanie peptida His-Phe-Arg-Trp-Pro-Gly-Pro na processy svobodnoradikal'nogo okisleniya v usloviyah hronicheskogo immobilizacionnogo stressa