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Bolezn' Parkinsona (BP) yavlyaetsya mul'tisistemnym zabolevaniem, pri kotorom nejrodegenerativnye izmeneniya s nakopleniem α-sinukleina zatragivayut volokna bluzhdayushchih nervov (BlN). Cel'yu dannoj raboty bylo provesti ul'trazvukovoe issledovanie (UZI) ploshchadi poperechnogo secheniya (PPS) BlN u pacientov s BP. V issledovanie voshli 32 bol'nyh BP (15 muzhchin i 17 zhenshchin; srednij vozrast 58 ± 10 let) i 32 cheloveka kontrol'noj gruppy, sopostavimye po polu i vozrastu. Vsem issleduemym provodili ul'trazvukovuyu ocenku PPS BlN datchikom vysokogo razresheniya. PPS levogo BlN u pacientov s BP byla men'she po sravneniyu s licami kontrol'noj gruppy (1,78 ± 0,52 mm2 protiv 2,11 ± 0,41 mm2; r = 007), dlya pravogo BlN analogichnoe razlichie polucheno na urovne tendencii. ROC-analiz pokazal, chto porogovaya velichina PPS dlya levogo BlN menee 2,10 mm2 imeet nizkij pokazatel' chuvstvitel'nosti (59%) dlya diagnostiki atrofii nerva pri BP. PPS pravogo BlN byla dostoverno vyshe, chem levogo BlN dlya pacientov obeih grupp (p &lt; 0,001). Pri analize gruppy bol'nyh BP ne vyyavleno zavisimosti PPS BlN ot vozrasta, prodolzhitel'nosti i stadii zabolevaniya, kolichestva ballov pri ocenke po motornoj (UPDRS III) i nemotornoj (NMSQ) shkalam. Pri etom u pacientov s akinetiko-rigidnoj formoj PPS levogo BlN byla znachimo men'she po sravneniyu s pacientami so smeshannoj formoj BP (r &lt; 0,05). Vyyavlena umerennaya obratnaya korrelyaciya PPS levogo BlN s ploshchad'yu giperekhogennosti chernoj substancii s obeih storon (r &lt; 0,04) i na urovne tendencii — dlya pravogo BlN. UZI pacientov s BP pokazalo atroficheskie izmeneniya BlN pri dannom zabolevanii, a takzhe vzaimosvyaz' PPS BlN s klinicheskoj formoj BP i ul'trazvukovymi izmeneniyami chernoj substancii golovnogo mozga.

Ul'trazvukovoe issledovanie bluzhdayushchih nervov u pacientov s bolezn'yu Parkinsona