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Rannyaya diagnostika processa metastazirovaniya pozvolyaet vybrat' optimal'nyj protokol lecheniya i povysit' vyzhivaemost' pacientok. Neinvazivnye i maloinvazivnye metody diagnostiki pomogayut stavit' diagnoz s minimal'nym ushcherbom dlya organizma. Cel'yu issledovaniya bylo najti biomarkery, harakterizuyushchie nachalo metastaticheskogo processa i sozdat' diagnosticheskuyu model' po lipidnomu profilyu plazmy krovi s ispol'zovaniem zhidkostnoj hromato-mass-spektrometrii. Issledovali plazmu krovi 55 pacientok, u 28 iz kotoryh bylo diagnostirovano metastazirovanie v regional'nye limfouzly, 27 pacientok sostavili kontrol'nuyu gruppu. Lipidy, otnosyashchiesya k okislennym lipidam i sfingomielinam imeli pri metastazirovanii statisticheski znachimo bolee vysokij i bolee nizkij urovni  sootvetstvenno. S ispol'zovaniem metodov mnogomernogo analiza byli sostavleny paneli lipidov, i modeli na ih osnove v hode kross-validacii po otdel'nomu ob"ektu imeli chuvstvitel'nost' i specifichnost' 79 i 74% (rezhim polozhitel'nyh ionov) i 50 i 85% (rezhim otricatel'nyh ionov).

Novye neinvazivnye podhody k diagnostike metastaticheskogo porazheniya limfouzlov pri rake molochnoj zhelezy metodom mass-spektrometrii