English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

V poslednee vremya metod fluorescentnoj mikroskopii priobretaet vse bol'shee rasprostranenie, otkryvaya novye vozmozhnosti dlya resheniya celogo ryada zadach eksperimental'noj biologii i mediciny. Cel'yu nastoyashchej raboty bylo ocenit' effektivnost' primeneniya metoda fluorescentnoj mikroskopii dlya identifikacii amiloidnyh skoplenij v tkanyah cheloveka. V kachestve materiala dlya issledovaniya byli ispol'zovany fragmenty miokarda (n = 12) i kory golovnogo mozga (n = 8) lyudej oboih polov v vozraste ot 60 do 98 let s verificirovannym amiloidozom. Preparaty okrashivali s primeneniem 11 raznyh gistohimicheskih krasitelej s posleduyushchim analizom metodami svetovoj i fluorescentnoj mikroskopii. Provedennye kachestvennyj i kolichestvennyj analiz pokazali, chto tioflavin T yavlyaetsya naibolee effektivnym krasitelem dlya fluorescentnogo vyyavleniya β- i transtiretinovogo amiloida v tkanyah cheloveka. Metodika okraski kongo krasnym obladaet vysokoj effektivnost'yu v otnoshenii transtiretinovogo amiloidoza, no ploho podhodit dlya identifikacii β-amiloidnyh blyashek. Ustanovleno, chto sposobnost' kongo krasnogo fluorescirovat' pri svyazyvanii s amiloidnymi fibrillami mozhet byt' ispol'zovana dlya verifikacii amiloidnyh skoplenij vmesto tradicionnoj polyarizacionnoj mikroskopii. Vpervye otmecheno, chto krasitel' metilovyj fioletovyj obladaet sposobnost'yu specifichno svyazyvat'sya s β-amiloidnymi skopleniyami s formirovaniem fluoresciruyushchego kompleksa, odnovremenno podavlyaya avtofluorescenciyu nervnoj tkani. Eto delaet metodiku okraski metilovym fioletovym perspektivnoj dlya diagnostiki patologii al'cgejmerovskogo tipa.

Primenenie gistohimicheskih krasitelej dlya fluorescentnogo vyyavleniya amiloidnyh skoplenij v tkanyah cheloveka