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32 The gram-negative gammaproteobacterium Escherichia coli (E. coli) was first discovered by Theodor Escherich in the stool samples of healthy individuals in 1885 [1]. E. coli naturally inhabits the lower intestines of warm-blooded species and is an important object of research. Four strains of E. coli, including K-12, B, W and С, are now used as model organisms. Strain K-12 was first isolated at Stanford university in 1922 [2]. Strain B was described by d’Herelle at the Pasteur Institute in Paris in 1918 [3]. The other 2 strains are less common. Strain C was discovered by Margaret Lieb in 1951 [4, 5], and strain W was originally reported by Selman Waksman in 1943 [6]. Strains comprising groups K-12 and B are the most widespread and best known. Laboratory strains have “evolved” to lose some of their properties, such as the ability to form biofilms on abiotic surfaces, and therefore can be advantageously used in research studies, especially for the discovery of novel antibiotics [7]. М. В. Каракозова , П. А. Назаров КОНСЕРВАТИВНОСТЬ ПОСЛЕДОВАТЕЛЬНОСТЕЙ ГЕНОВ ПОМПЫ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ ACRAB-TOLC ESCHERICHIA COLI КАК ПРИЗНАК ВОВЛЕЧЕННОСТИ В ПЕРМАНЕНТНУЮ «УБОРКУ» БАКТЕРИАЛЬНОЙ КЛЕТКИ

bulletin of russian state medical university/bulletin of rsmu

Conserved sequences of genes coding for the multidrug resistance pump AcrAB-TolC of Escherichia coli suggest their involvement into permanent cell “cleaning”