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A better understanding of the forces controlling cell growth will be essential for considering wound healing as a fundamental evolutionary with possibility of scar formation and reparative regeneration and the developing effective therapies in regenerative medicine and also in cancer. Historically, the literature has linked to cancer and tissue regeneration-proposing regeneration as both the source of cancer and a method to inhibit tumorigenesis. Aim of this work is to verify similarity and difference between this processes an evolutionary approach. The same verify the evolution of some factors involved in cancer development. In all this process, genetically conserved or not. There are determinate kind of program (finalistic or afinalistic) whit a start messages but also a stop when the scope is achieved (regeneration). It is clear that regeneration abilities in adult form is reduced in some superior vertebrates like humans and the same it seem related to an introduction of adaptative immunity. This review discusses two powerful regeneration models, the vertebrate urodele amphibians and invertebrate, in light of cancer regulation.

international journal of cancer and clinical research

Regeneration Abilities of Vertebrates and Invertebrates and Relationship with Pharmacological Research: Hypothesis of Genetic Evolution Work and Microenvironment Inhibition Role