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Background: Circadian rhythms influence the pharmacology and effects of anesthetic agents such as local anesthetics, general anesthetics, and muscle relaxants. However, the influences of the circadian rhythm on new anesthetics such as propofol are unknown. Method: Propofol, one of popular intravenous anesthetics, was administered intravenously using the Diprifusor™ system, which is a target-controlled infusion system of propofol. The propofol infusion started with an initial effect-site concentration of 4μg/mL for 3 min and increased in increments of 0.5μg/mL every 30 sec after the first 3 min until the patient lost the eyelash reflex and exhibited no response to verbal commands. The predicted blood concentration and the predicted effect-site concentration of propofol required for loss of consciousness (LOC) were recorded. Results: Thirty-seven patients underwent induced anesthesia at 8:30. Twenty-eight patients were induced between 14:00 and 16:00.There was no significant difference between the two groups in the predicted blood concentration, the predicted effect-site concentration and the time for LOC. Conclusion: The concentration for LOC by propofol is not influenced by the time of day, at least during the human active period.

The Concentration for Loss of Consciousness by Propofol does not differ between Morning and Afternoon