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A model is offered towards an understanding of the cellular communications of two major cell types of the pancreas. The beta and alpha cells of the pancreas are considered to be coupled by the insulin and glucagon hormones that they produce, respectively. In this model, insulin stimulates the alpha cells to release glucagon and grow, especially by cell division, while glucagon similarly stimulates the beta cells to release insulin and grow. Of equal importance to the system is the concentration of the insulin:glucagon complex to which the beta and alpha cells are directly exposed in the pancreatic environment. Its measurement by the cells allows each coupled cell to gauge the activity of the other cell.

Alpha- and Beta-Cell Proliferation and Extracellular Signaling - A Hypothesis