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Development of two comprehensive population-wide e-cohorts, derived utilising data linkage techniques and including multisourced anonymised routine health and demographic data held within the SAIL Databank. The objective is to characterise multi-morbidity and its clustering, determinants and outcomes and compare methods using a) prospective cohort design using multiple data sources in Wales and b) retrospective cohort design to examine household level and environment clustering using GP data in demographically diverse populations (Wales and North East London). The prospective e-cohort focuses on adults living in Wales on 1st January 2000 and followed up to 2020, including data from the NHS population register, deaths, inpatients, outpatients, Emergency Department, GP, disease registries, laboratory data, and population surveys with QoL measures. This e-cohort will be harmonised with other sites across the UK. The retrospective e-cohort is designed to harmonise with a North East London e-cohort, including all individuals living in Wales on 24 th April 2018 and registered with a GP. Results

international journal of population data science

The Development and Implementation of The Wales Multi-Morbidity Electronic Cohort: Prospective and Retrospective Study Designs to Investigate Multi-Morbidity