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Background: Psoriasis is a chronic autoimmune condition characterized by infiltration of keratinocytes by inflammatory cells that cause scaling on the skin surface. Psoriasis is considered now as T cell-mediated disease. INFγ is considered a key cytokine in the pathogenesis of psoriasis. Objectives: To evaluate the level of IFN gamma in order to recognize its role in the pathogenesis of psoriasis and its relation to the severity of the disease. Materials and Methods: We investigated the level of serum IFN-γ in 40 patients with psoriasis and in 25 healthy controls by ELISA Kit. We used the PASI score to assess the severity of psoriasis. Results: The serum levels of IFN-γ were elevated in all patients with psoriasis but not in all healthy controls. Also, the serum levels of IFN-γ were correlated with the severity of disease in psoriatic patients. Conclusion: The level of IFN-γ can be used as a useful estimate of the severity of the disease and may be used in daily practice as prognostic follow-up marker. Keyword: Psoriasis; IFN-γ; PASI score Abbreviations: KCs: Keratinocytes; DCs: Dendritic Cells; IFN-γ: Interferon-Gamma; PASI: Psoriasis Area and Severity Index; SPSS: Statistical Package for Social Science; SD: Standard Deviation; ELISA: Enzyme-Linked Immunosorbent Assay. Research Article Volume 1 Issue 1 Received Date: September 05, 2019 Published Date: October 03, 2019 Annals of Immunology & Immunotherapy Gharib AF, et al. Assessment of the Level of Interferon-Gamma in the Pathogenesis of Psoriasis. Ann Immunol Immunother 2019, 1(1): 000106. Copyright© Gharib AF, et al. 2