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In recent years the number of postmortem cases in which cocaine involvement is suspected has increased considerably. This has created a need for a rapid screening procedure for the postmortem samples. The present study examined the usefulness of vitreous humor specimens, analyzed by a rapid immunological assay, as a possible alternative to the more conventional and relatively slow gas chromatography/mass spectrometry of blood samples to screen for antemortem cocaine use. Medical examiner cases occurring over a six month period were reviewed and forty-ei~ht cases which were determined to be drug related or drug induced deaths were analyzed. Postmortem concentrations of cocaine and its hydrolysis product, benzoylecgonine, recovered from blood, were compared to the concentrations detected in vitreous humor. These specimens were screened via a rapid fluorescence polarization immunoassay (FPIA) and also analyzed by gas chromatography/ mass spectrometry (GC/MS) for a quantitation of cocaine and its primary hydrolysis product, benzoylecgonine. An assessment of FPIA to screen postmortem vitreous humor samples was carried out. The sensitivity of this method was 0.03 mcg/ml. The vitreous humor cocaine metabolite levels by FPIA and GC/MS demonstrated a correlation coeificient of 0.7. Blood and vitreous humor benzoylecgonine levels from the same postmortem case analyzed by GC/MS showed a correlation coef-

FLUORESCENCE POLARIZATION IMMUNOASSAY OF VITREOUS HUMOR TO DETECT DRUG USE