English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The effect of guanethidine (1.20 mg/kg, i.p.) or reserpine (0.2 mg/kg, i.p.) has been compared on various indices of pituitary-adrenal stimulation in rats subjected to chronic forced restraint for 24 days. This was accomplished by analyzing the serum corticosterone, the adrenal ascorbic acid (AAA) and various organ weights such as the adrenals, brain and heart. Peripheral and central norepinephrine (NE) was also measured. Chronically stressed, control rats or those treated with guanethidine demonstrated both behavioral and neurochemical adaptation. Initial excitation associated with restraint was related to changes in NE in the brain and heart. As the experiment progressed, the stressed, guanethidinetreated animals showed changes in peripheral NE that were similar to those of the stressed, vehicle-treated animals; whereas, the non-stressed guanethidine-treated animals showed a progressive decline in peripheral NE over the 24 day study. This change in the peripheral NE in the stressed, guanethidine-treated animals was attributed to increased production of NE, perhaps by the adrenals, since low doses of guanethidine do not affect adrenal catecholamines. Reserpine-treated, stressed animals showed 40% mortality over the 24 day period, thus indicating non-adaptation. This increased mortality was not due to starvation or decreased water intake. It is suggested that non-adaptation in these animals may be due to a chemical sympathectomy, and the animals were unable to respond to severe · changes · in the environment. Changes in behavior, in the different groups of animals, were correlated with changes in brain NE. Evidence is also presented indicating that reserpine and guanethidine do not deplete heart NE by the same mechanism(s). iv

Differential Effects of Guanethidine and Reserpine on Norepinephrine in the Brain and Heart of Male Albino Rats Subjected to Restraint