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Massive localized lymphedema (MLL) is an emerging complication of the obesity epidemic and a challenging clinical entity mimicking liposarcoma. It presents as an ill-defined mass of the proximal medial extremities in morbidly obese adults (1). MLL is caused by the compression of regional lymphatic vessels by massive adipose tissue (1–3). Although benign, the diagnosis can be challenging since atypical lipomatous tumors and liposarcomas present in the same manner (2, 3). Furthermore, MLL can transform to an angiosarcoma, in a phenomenon known as Stewart-Treves syndrome (2, 3). This case highlights the need for clinical vigilance for dermatologists to recognize this entity morphologically and to institute appropriate investigation and management.

Massive Localized Lymphedema, an Emerging Problem and a Challenging Pseudosarcomatous Condition Mimicking Liposarcoma