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Sjogren's syndrome (SS) is an autoimmune disorder characterized by exocrine dysfunction, such as xerophthalmia or xerostomia, focal lymphocytic sialoadenitis, and a high titre of autoantibodies inclusive of anti-Ro and anti-La. SS is also associated with both organic dermatological disorders and neuropathy. Dry skin is a complication in 23-67% of patients with SS, especially those under 50 years of age (1). Two cases of acquired generalized hypohidrosis/anhidrosis (AGHA) associated with subclinical SS and absence of dryness of the eyes and mouth have been described previously (2, 3). In addition, peripheral neuropathy, the spectrum of which includes autonomic neuropathy, is the most common neurological complication of SS, with a prevalence ranging from less than 2% to greater than 60% (4). Autonomic neuropathy may cause symptoms such as orthostatic hypotension, bowel dysfunction and anhidrosis. We report here a case of subclinical SS-associated AGHA.

Skin Ultrastructural Findings in Acquired Generalized Hypohidrosis/Anhidrosis in a Patient with Subclinical Sjögren Syndrome