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Stevens-Johnson syndrome (SJS) is a rare but extremely severe drug-induced eruption characterised by widespread necrosis or apoptosis of the epidermis (1). The main causal factor for SJS is an aberrant activation of CD8 T cells. Although the dysfunction of the regulatory T cells (Treg) is considered a possible cause of excess CD8 T cells activation (2), the actual significance of Tregs in vivo remains unknown.

Stevens-Johnson Syndrome Associated with Mogamulizumab-induced Deficiency of Regulatory T cells in an Adult T-cell Leukaemia Patient