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© 2014 The Authors. doi: 10.2340/00015555-1720 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Rheumatoid nodules are characterised by subcutaneous nodular lesions at pressure areas, such as finger joints and the extensor area of the forearm. Rheumatoid nodules occur in approximately 30–40% of patients with rheumatoid arthritis (RA), and usually reflect high levels of disease activity and severity of RA (1, 2). Rheumatoid nodules are often confused with methotrexate (MTX)-induced accelerated nodulosis. MTX-induced accelerated nodulosis is characterised by multiple subcutaneous nodules occurring during MTX treatment for RA, and is seen in 8% or 11.6% of MTX-treated patients (3–5). Herein, we report a case of accelerated nodulosis during MTX therapy in a patient with RA and scleroderma.

Methotrexate-induced Accelerated Nodulosis in a Patient with Rheumatoid Arthritis and Scleroderma