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© 2012 The Authors. doi: 10.2340/00015555-1270 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Sezary syndrome is an erythrodermic cutaneous T-cell lymphoma with haematological evidence of leukemic involvement, which is typically characterized by a monoclonal proliferation of atypical CD4+CD45RO+ lymphocytes (Sezary cells). We report here a case of CD8+ Sezary syndrome that was treated successfully with methotrexate. Sezary cells were CD3+, CD4–, CD8+, CD45RO+. They also expressed CC chemokine receptor 4 and 10, but not CXC chemokine receptor 3. The number of Sezary cells and serum levels of soluble IL-2 receptor were positively correlated with serum levels of CC chemokine ligand 17, 22 and 27, whereas they were negatively correlated with serum levels of CXC chemokine ligand 10.

Serum Levels of CC Chemokine Receptor 4 and CXC Chemokine Receptor 3 Ligands in CD8+ Sézary Syndrome