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© 2011 The Authors. doi: 10.2340/00015555-1143 Journal Compilation © 2011 Acta Dermato-Venereologica. ISSN 0001-5555 Merkel cell carcinoma (MCC) is a neuroendocrine malignant neoplasm that primarily affects sun-exposed skin of older Caucasian and/or immunosuppressed persons (1, 2). Its biological behaviour is highly aggressive, with high rates of metastasis and poor survival (1). Merkel cell polyomavirus (MCPyV) was identified in January 2008 by Feng et al. (3) in tumour tissue from MCC patients, proving clonal integration of the virus DNA into the host genome. Meanwhile, several studies confirmed this observation, showing frequent prevalence of MCPyV DNA in MCCs (2, 4, 5), suggesting MCPyV as the likely causative agent of MCC. Presence of MCPyV DNA in MCC seems to be a relevant favourable prognostic factor (5) and MCCs potentially have different invasion and metastatic properties depending on their MCPyV DNA status. This is the first report analysing CK20, CK19, CD117 and ST3 protein expression of tumour cells as a function of presence of MCPyV DNA in a large cohort of MCC.

Immunohistochemical Features of Merkel Cell Carcinoma in Correlation with Presence of Merkel Cell Polyomavirus DNA