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Spitz naevus is a melanocytic lesion that is characterized by neoplastic proliferation of epithelioid and/or fusiform-shaped cells. Rare variations of Spitz naevus, such as desmoplastic, hyalinizing, plexiform, pagetoid, pigmented fusiform and angiomatoid Spitz naevus have been described (1). Desmoplastic Spitz naevus (DSN), first described by Reed et al. in 1975 (2). Histopathologically, desmoplastic Spitz naevus is characterized by epithelioid and/or fusiform-shaped cells surrounded by a fibrous stroma consisting of thick bundles of collagen. It has clinical and histopathological features that are difficult to differentiate from dermatofibroma and desmoplastic malignant melanoma (DMM), which requires aggressive therapy for cure.

Desmoplastic Spitz Naevus Can Be Mistaken for Desmoplastic Malignant Melanoma and Dermatofibroma