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© 2010 The Authors. doi: 10.2340/00015555-0917 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 Acne vulgaris is a common skin disorder that affects 80–85% of teenagers and may continue into adulthood. Clinical studies suggest that 5-aminolaevulinic acidbased topical photodynamic therapy (ALA-PDT) is a potentially useful modality for inflammatory acne and for patients who are unable to tolerate isotretinoin or antibiotics (1). ALA is a prodrug that can be converted intracellularly by the haem biosynthetic pathway into the active photosensitizer protoporphyrin IX (PpIX). ALA degrades in the skin with a half-life of 24 h and endogenous PpIX-mediated photosensitization can last for up to 48 h, although it can be prevented by strict avoidance of exposure to light (2). The common acute adverse events of topical ALA-PDT are pain during exposure to light and mild acute inflammatory response (e.g. erythema) after exposure to light (3). In general, complete healing with good to excellent cosmetic outcome occurs within 2 weeks post-PDT. However, the potential risk of cutaneous photosensitization associated with light sources other than sunlight and bright electric lights may be underestimated. We describe here a case of persistent erythemal reaction after topical ALA-PDT due to long exposure to light from a cathode ray tube (CRT) monitor.

acta dermato-venereologica

Cutaneous Photosensitization Induced by Exposure to Colour Cathode Ray Tube Monitor Following Topical 5-Aminolaevulinic Acid-based Photodynamic Therapy: A Case Report