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The relaxing effects of protease inhibitors, EACA, PAB and aprotinin on the Ach-contracture of ABRM ofMytilus edulis were observed by measuring the half-relaxation time of Ach-contracture in comparison with the effects of serotonin and dopamine on it.1. Serotonin and dopamine rapidly relaxed Ach-contracture of ABRM. These effects were dependent on the concentration of those two agents and consistent with those of other investigators.2. EACA, PAB and aprotinin relaxed Ach-contracture of ABRM, and showed the lower potency as compared with serotonin and dopamine in relaxing action. These effects were dependent on the concentration of those agents by 10-4 M, respectively.The significance of the results obtained was also discussed in relation to protease, contractile elements and elements maintaining prolonged contraction induced by Ach in ABRM.

Influences of Serine Protease Inhibitors on the Relaxation in Acetylcholine-Contracture of Anterior Byssal Retractor of Mytilus Edulis