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The present study was carried out to investigate tissue enzymes available as indicators for Cd water pollution. Carp (Cyprinus carpio, 304±55g in body weight) were exposed to Cd (50μg/l, CdCl2⋅21/2H20) for 2 and 6 weeks. There were no effects on hematoclit value and hemoglobin concentration after 2 week exposure and on serum Ca, inorganic P, Na and K concentrations after 2 and 6 week exposure, while after 6 week exposure hematoclit value and hemoglobin concentration decreased. These decreases indicate that the Cd-exposed fish were anemic. Because the serum GOT, GPT, Al-P, Acid P and LDH activities of Cd-exposed fish did not significantly change and showed remarkable variation, these were not available as indicators.There were no effects on the activities of Al-P and LDH in hepatopancreas, Al-P in kidney and ChE in brain. On the other hand, the activities of GOT and GPT in hepatopancreas and Al-P in gill inclined to decrease, while the activities of Acid P in hepatopancreas, kidney and gill and LDH in kidney inclined to increase. But there were no necessarily proportional dose-response relationships between activities of tissue enzymes and Cd content in hepatopancreas.In conclusion, these results indicate that Cd exposure produces effects on the activities of GOT and GPT in hepatopancreas, Al-P in gill, Acid P in hepatopancreas, kidney and gill and LDH in kidney. Especially, Acid P activity in each tissue is considered to be one of the most suitable indicators for Cd water pollution.

The effects of cadmium on the activities of tissue enzymes of fish.