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Polymorphisms of the Calpain10 and TCF7L2 genes were identified as possible   type 2 diabetes susceptibility genetic markers. We conducted a case-control   study to evaluate the relation between SNP43 of calpain-10 and rs12255372 and   rs7903146 in the TCF7L2 with type2 diabetes in western-north of Iran. The   role of these variants in Iranian population was less clear. A total of 202   patients and healthy controls were enrolled to analysis the frequency   distribution of Calpain10 and TCF7L2 polymorphisms (SNP43, rs12255372 and   rs7903146) using polymerase chain reaction-restriction fragment length   polymorphism (PCR - RFLP) method. The frequency of allele A in controls was   significantly greater than that of diabetic patients (P=0.031), whereas the   difference between distribution of SNP43 genotypes (A/A, A/G, G/G) were non-   significant in case and control groups. Non significant association was also   observed between G/G, A/G or A/A genotypes and type 2 Diabetes. The frequency   of the “T” allele of rs12255372 (G/T) was significantly associated with type   2 diabetes (OR= 0.55, 95% confidence interval [CI], 1.11-1.51; P<0.001). No   allelic association was found for rs7903146(C/T) polymorphism. The   distribution of alleles in case and control groups are significantly   different indicating the G allele is associated with type 2 diabetes. The   rs12255372 (G/T) may be associated with type 2 diabetes

A study on association of polymorphisms in calpain10 and TCF7l2 genes with type 2 diabetes mellitus