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Cadmium (Cd) is one of the most toxic industrial and metal in the environment   which may cause severe genotoxic effects. The aim of the work was an   evaluation of genotoxic effects of CdCl2 in genetically pure Albino Oxford   (AO) rats, depending on sex, age and dosage. Experimental animals were   treated intraperitoneally with three different concentrations of CdCl2: 0.5,   1, and 2 mg/kg of CdCl2, while the control animals received equal volume of   sterile phosphate buffered saline. The individuals of both sexes were treated   at the age of 3, 6 and 12 month. Frequency of micronuclei formation was   evaluated in polychromatic erythrocytes (PCEs), 24h hours after the   treatment. The results showed that CdCl2 caused a concentration-dependent   increase of micronucleus frequency. The most significant differences were   found between ages of 3/12 and 6/12 months at 0.5 and 1.0 mg CdCl2   concentrations. Namely, 3 month old males had higher frequency of MNi in   comparison to 12 month old males, whereas in females it was the opposite.   Likewise, 6 months old males exbibited greater sensistivity to CdCl2 in   comparison to 12 month old rats, and in the females it was the opposite. Sex   differences were further confirmed as slightly stronger genotoxic effects in   12 months old females treated with 0.5 and 1 mg/kg of CdCl2. Therefore, the   genotoxic effects of cadmium in AO rats depend on concentration, age and sex.   [Projekat Ministarstva nauke Republike Srbije, br. III46002 i br. OI173012

Induction of micronuclei by cadmium chloride in AO rats depends on age and sex