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Apolipoprotein E (ApoE) play important role in lipid metabolism and in   processes of remodeling and reparation in central nervous system. Three   common ApoE isoforms, ApoE2, ApoE3 and ApoE4, show strong genetic   determination by ε2, ε3, and ε4 allele. In human genome gene encoding   Apolipoprotein E (APOE) is located on cromosome 19, and ε2/ε3/ε4 haplotype   system is defined by 2 non-synonymous single nucleotide polymorphisms (SNPs)   in the APOE exon 4. The frequency of the three APOE alleles and corresponding   genotypes varies across human populations, with possible clinical   implications. At least, variable distribution of ε4 allele may contribute to   the regional risk of cardiovascular and Alzheimer’s diseases.   Allele-frequency comparisons between younger and older populations suggest an   effect of APOE on mortality, but these data are not consistently confirmed.   In the present study we have analyzed the distribution of APOE gene   polymorphism in a group of University students and retained University   professors living in Serbia. After DNA extraction from peripheral blood   samples, the APOE genotype was determined by polymerase chain reaction (PCR)   followed with HhaI restriction digestion. We found no statistically   significant difference in alleles and genotypes distribution between younger   and elder group of participants. Also, there was no significant difference   compared to APOE data previously obtained in YUSAD cohort of healthy school   children (15 y of age) from different regions of Serbia. In both of our   groups, as well as in YUSAD cohort, frequency of APOE ε4 allele was <10%. The   observed frequencies are lower than in neighboring countries, but similar   with Spanish data and some Asian populations. Our results do not support   important role of APOE ε4 in the morbidity and mortality in Serbian   population, but gene-environmental-social interactions should be considered.   [Projekat Ministarstva nauke Republike Srbije, br. ON175091

Distribution of apolipoprotein E gene polymorphism in students and in high-educated elderly from Serbia