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Hematopoietic stem cells (HSCs), which under physiological conditions are a heterogeneous population of cells of varying degrees of maturity, are precursors to all cells of the immune system, except for stromal ones. They constitute in general a well-known continuum of HSCs and their progenitors whose elements differ fundamentally in the range of multipotency and sensitivity to humoral and intercellular contact regulation [1]. Transplantation of HSCs and progenitors to irradiated animals provides restoration of the immune system and protects them from the development of the lethal bone marrow failure syndrome. But sometimes the results are not quite satisfactory and the question arises whether this is due to insufficient number of HSCs in cell transplant as well as multipotent stromal cells (MSCs), which usually perform an important function of The effects of the transplantation of thymus-derived multipotent stromal cells on the immune system and survival of lethally irradiated mice Cell and Organ Transplantology. 2018; 6(2):158-163. doi:10.22494/cot.v6i2.88