English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: NecroX-5 has been evaluated to have anti-necrotic potential on ischemia reperfusion injury (IRI) in skin flaps. Nevertheless, there is no study focusing on the underlying mechanism involved in this protective effect. We used NecroX-5 to assess the preventive effect and regulatory mechanisms on flap survival in rat model. Methods: Twenty male Sprague-Dawley rats were allocated into two groups with 10 each: control IRI group and IRI with 30 mg/kg of NecroX-5-treated group. On postoperative day 7, viable area of the skin flap was measured and specimens were used for immunohistochemical analysis. Results: The necrotic area of NecroX-5 group was significantly lower than those of control group (NecroX-5 group: 6±0.019%; control group: 38±0.11%; P<0.05). Furthermore, levels of interleukin-1β and tumor necrosis factor-α were markedly lower in NecroX-5 groups than in control groups and NecroX-5 groups resulted in an apparent decrease of infiltrating immune cells. Conclusion: We suggest that NecroX-5 acts as a protective factor during IRI of skin flaps by inducing a negligible amount of proinflammatory cytokines.

The Protective Effect of NecroX-5 on Flap Survival and Ischemic Reperfusion Injury Inflammation in Rat Model