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The antitussive-expectorant effects of two phytotherapic formulations of Brazilian market were evaluated using three different biological models. Each phytotherapic formulation, with different composition, had the same batch number and fabrication date. The trade names of phytotherapics were: Extrato Expectorante Salva and Xarope Expectorante e Sedativo da Tosse Fitomed. A specific animal specie was used in each evaluated model (n=10 animals/group). Wistar rats in the airway secretion model, guinea pigs in the citric acid-induced cough model and japanese quails in the mucociliary trans-port rate determination were used. The animals (one group/formulation) were divided in the two phytotherapic groups, and treated orally with the equivalent to ten times the therapeutic recommended dose (9mL.kg -1 ). A negative control group each specie was treated orally with saline (10mL.kg -1 ). Positive guinea-pigs citric acid-induced cough model was treated with morphine (1mg.kg -1 ) subcutaneously. In the rat airway secretion model and japanese quails mucociliary transport rate, a positive control received orally erdosteine (600mg.kg -1 ). The results showed that the six phytotherapic formulations were able to inhibit the guinea pig cough reflex induced by citric acid. The rat airway secretion and the mucociliary transport rate were not significantly affected by the two phytotherapic formulations.

Efeitos antitussígenos e expectorantes de dois fitoterápicos comercializados no mercado brasileiro