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Background and Objective The aim of this study was to determine how resistance training and detraining later affected growth factors, inflammatory markers, and bone metabolism markers in healthy male college students. Material and Methods Twenty-two young adults participated in 12 weeks weight training program. Exercise intensity for weight training group (WT) included the following: step 1; 70 % of 1 repetition maximum (1RM), step 2; 80 % of 1RM, step 3; 90 % of 1RM. After 12 weeks, randomly assigned to the 6 weeks of CT (continued training group)(N=11) and 6 weeks of DT (detraining group)(N=11). In the body composition test, height, weight, BMI (body mass index), %fat, and LBM (lean body mass) measured by electric impedance. Blood collection was carried out before, after 6 weeks, after 12 weeks, and after 18 weeks of training. In blood analysis, growth factors(GH, IGF-1, testosterone), inflammatory markers(IL-6, TNF-α, CRP) and bone metabolism markers(OC, ALP) were analyzed. Results Results showed that IGF-1 level was significantly (p < 0.05) decreased after 12 weeks of training compared to that prior to training. Testosterone level was also significantly (p < 0.05) decreased after 6 weeks and 12 weeks of training. Levels of IL-6, TNF-α, CRP showed no significant differences by training period. Both OC and ALP were significantly (p < 0.05) increased after 6 weeks and 12 weeks of training compared to those prior to training. Detraining period IGF-1 level after 18 weeks was higher (p < 0.05) than that in the CT group after 12 weeks IL-6 level after 18 weeks was lower compared to that at 12 weeks in the CT group. TNF-α level after 18 weeks was decreased compared to that after 12 weeks in both groups. ALP level after 18 weeks was significantly increased compared to that after 12 weeks in the CT group. Conclusions Metabolic markers gained induces and reduces due to resistance training and detraining. After 12 weeks resistance training induced bone metabolic markers(OC, ALP). In addition, training period of more than 18 weeks is needed to reduce inflammatory markers(IL-6, TNF-α). Six weeks of detraining does not affect metabolic markers in healthy young adults.

EFFECT OF RESISTANCE TRAINING AND DETRAINING ON METABOLIC MARKERS