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The present management line of osteoarthritis of the knee is mostly symptomatic, therefore the need to investigate treatment modality which addresses the disease process in itself. This study was undertaken to evaluate the efficacy of platelet-rich plasma in primary osteoarthritis of the knee. Materials and Methods: This prospective study was done on 62 knees in 50 patients of early primary osteoarthritis of the knee. Three injections of platelet-rich plasma were given at four weeks interval and the outcome was evaluated using WOMAC and VAS score at pre-injection, 3 weeks, 12 weeks, and 24 weeks. Ahlback’s grading was done at pre-injection and 6 months. Results: Most of the cases in our series were in the age group of 51-60 years with female predominance, 38 cases had grade 2 disease and the remaining had grade 1 involvement. Improvement in WOMAC score parameters started at 3 weeks with progressive improvement at subsequent follow-ups. WOMAC score parameters (pain, stiffness, physical function, and total score) at pre-injection were 15.28, 6.16, 38.46, and 58.68 and at 6 months follow up were 6.02, 2.01, 18.46 and 26.51 respectively. A similar improvement was seen in the VAS score with a pre-injection score of 6.48 and a final score of 3.56. The average WOMAC score was less for grade 1 as compared to grade 2. Improvement was seen in most cases though the level varied from good to mild improvement. There was no complication related to the treatment in our series. Conclusion: It is evident from the study that PRP is an effective modality of treatment. However, further high evidence studies are required to look for the long-term effects and to confirm the findings of this study.

A study on the outcome of platelet-rich plasma in the management of primary osteoarthritis of knee in Northern Andhra Pradesh