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The purpose of this study was to develop fast dissolving tablets of Aceclofenac using different concentration of super disintegrants. Fast dissolving tablets of Aceclofenac were prepared by dry granulation technique using croscarmellose sodium together with avicel ph as superdisintegrants. The porous granules were then compressed in to tablets by direct compression technique. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and dispersion time. All the formulations showed low weight variation with dispersion time less than 90 seconds and rapid in vitro dissolution. The drug content of all the formulations was within the acceptable limits. The optimized formulation showed good release profile i.e. maximum drug being released at all-time intervals compared to other trial batches. It was concluded that fast dissolving tablets with improved dissolution could be prepared by dry granulation method of tablet.

Formulation and Characterization of Aceclofenac Mouth Dissolving Tablet by QbD