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The newly synthesized compounds are being tested for in vitro anti-cancer activity. Method used for In Vitro testing is Sulforhodamine B assay also known SRB assay. Cell lines were prepared and homoginised and disassociated with the help of trypsin. Then trypsin was inactivated with fetal bovine serum. Then cell concentration was determined. Synthesised molecules where prepared in to four different dillutions and exposed to cell lines. The procedure was also compared with standard drug doxorubicin. All the cell medium was incubated 37 degrees centigrade in a humidified incubator with 5 percentage CO. The plates were stainned and fixed with trichloroacetic acid. Finally the plates were incubated in orbital shaker incubater and absorbance was measured in micro plate reader at 510nm. All compounds (1-30) showed similar anticancer activity of compounds (IA, IB, ID,IE,IF, IIB,IIC, IIIA, IVB, IVF, VA, VC, VD, VE.) were more potent when compared to the rest of the compounds synthesized.

IN VITRO SULFORHODAMINE B ASSAY EVALUATION OF NOVEL 2-PHENYL BENZOFURANONE DERIVATIVES ON HUMAN SKIN CANCER CELL LINE G361.