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Aim: Traumatic brain injury is a complex condition consisting of a mechanical injury with neurovascular disruption and inflammation with limited clinical interventions available. A growing number of studies report systemic delivery of human umbilical cord blood (HUCB) as a therapy for neural injuries. Materials &amp; methods: HUCB cells from five donors were tested to improve blood–brain barrier integrity in a traumatic brain injury rat model at a dose of 2.5 × 10 7  cells/kg at 24 or 72 h postinjury and for immunomodulatory activity in vitro. Results &amp; Conclusion: We observed that cells delivered 72 h postinjury significantly restored blood–brain barrier integrity. HUCB cells reduced the amount of TNF-α and IFN-γ released by activated primary rat splenocytes, which correlated with the expression of COX2 and IDO1.

Human umbilical cord blood cells restore vascular integrity in injured rat brain and modulate inflammation in vitro