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Aim: Describe rates of prespecified adverse events in patients who switched from olaparib capsules to tablets. Patients &amp; methods: Retrospective, observational cohort analysis using self-controlled, pre–post design. Data on patients with ovarian cancer who switched from olaparib capsules to tablets between January 2015 and February 2019 were obtained from a US claims database. Results: Among all patients (n = 48), proportion with any prespecified adverse event was 45.8% (95% confidence interval: 31.4–60.8) during initial 90 days’ capsule use and 35.4% (22.2–50.5) during initial 90 days’ tablets use; difference -10.4% (-28.8–9.0). Conclusion: Switching from olaparib capsules to tablets was manageable with no evidence of increased toxicity. This real-world study supports the manageable tolerability of olaparib in women with ovarian cancer.

Adverse events in women switching from olaparib capsules to tablets: retrospective observational study of US claims data