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Klebanov et al. (2006) proposed a new type of stochastic dependence, Type A dependence, between gene expression levels. They estimated the abundance of Type A pairs by testing the correlation coefficients of gene pairs. We propose a new model, hidden regulator dependence, as an alternative to Type A dependence. We show that the correlation based procedure proposed by Klebanov et al. (2006) fails to differentiate hidden regulator dependence from Type A dependence, although their probabilistic structures are quite different.

An Alternative Model of Type A Dependence in a Gene Set of Correlated Genes