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Title: Effectiveness of endoscopic endonasal transsphenoidal surgery using a neuronavigation: Clinical results of 178 pituitary adenomas Background: The present study assesses endoscopic endonasal transsphenoidal surgery using neuronavigation for pituitary adenoma. Methods and findings: Data were analyzed from 178 consecutive patients with pituitary adenomas who underwent endoscopic endonasal transsphenoidal surgery using neuronavigation between April 2007 and May 2014. Rates of gross total removal and overall hormone remission in patients with microadenomas were 64% (114/178) and 90.9% (30/32), respectively. However, the rate of hormonal remission was lower for macroadenomas that produce growth hormone 64.3% (9/14). The rate of complications was 2.1% (4/178) including two patients with anterior pituitary insufficiency and one each with vision deterioration and permanent diabetes insipidus. Conclusion: Rates of complete removal and hormone remission were higher and complication rates were lower after endoscopic endonasal transsphenoidal surgery using neuronavigation to treat pituitary adenoma.

Effectiveness of Endoscopic Endonasal Transsphenoidal Surgery Using a Neuronavigation: Clinical Results of 178 Pituitary Adenomas