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Differential diagnosis between radiation necrosis and tumour recurrence is important in the clinical manage- ment of patients with glioma. We performed an overview of the literature in order to summarize the role of 11 C- methionine positron emission tomography (MET-PET) in this setting. This functional imaging method appears to have a high sensitivity, specificity, and accuracy in differentiating between glioma recurrence and radiation necrosis. Neverthe- less, possible false negative and false positive results of MET-PET should be well kept in mind in the management of pa- tients with glioma.

the open neurosurgery journal

Usefulness of 11C-Methionine Positron Emission Tomography in Differential Diagnosis between Recurrent Tumours and Radiation Necro-sis in Patients with Glioma: An Overview