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Rationale and aim: Nasal congestion is a common symptom in allergic and non-allergic rhinitis, rhinosinusitis and nasal polyposis. Although various pharmacotherapy options exist, no agent is universally efficacious. The aim of this study was to evaluate the clinical effectiveness efficacy of Narivent ® , which is an osmotically acting medical device with anti-oedematous and anti-inflammatory effects, in a long-term (30 days) treatment. Methods: A single-centre prospective study with a pre-post design was conducted with consecutive enrolment in an Italian Otolaryngology Department of 56 both genders patients with persistent nasal congestion. Patients received 2 puffs of Narivent ® into each nostril 2 times a day over the course of 4 weeks. The severity of symp- toms was assessed subjectively as measured by a 0 to 10 visual analogue scale (VAS) and the presence/absence of symp- toms and signs. Differences in subjective and objective severity measures before and after treatment were compared using Paired-Sample Wilcoxon Signed Rank Test. Results: A significant improvement after treatment (p<0.001) has been recorded for the main subjective symptoms and objective signs (overall symptom burden, nasal congestion, cephalea, rhinorrhea, hyposmia, turbinates hypertrophy, mu- cosa status). Conclusion: Study results confirm the efficacy of Narivent ® in treating nasal congestion over a 4 weeks period.

Short-term Efficacy of Narivent® in the Treatment of Nasal Congestion