English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective: To model the healing that umbilical cord perivascular cells effect in equines, we have used human umbilical cord perivascular cells (HUCPVCs) to repair tendon damage in a collagenase tendon injury model in immune- compromised rats. Animals: 48 Nude rats (Crl:NIH-Foxn1 rnu ) of 200-250 g weight were used. Procedure: The Achilles tendon was exposed by blunt dissection and, using a 30G needle, 30 µl of either a mixture of cells (2 x10 5 ) and collagenase, or collagenase alone, was injected close to the musculotendinous junction in the direction of the osteotendinous junction. Results: Harvested tendons showed the presence of HUCPVCs at the site of injury, whose morphology changed from ovoid to elongated over the 30 post-injury experimental time period. Human genes for collagen type 1 and β-actin were expressed at all time points and there was also a significant increase in tendon tensile strength and stiffness by 30 days post-injury in the experimental group. Conclusion: HUCPVCs facilitated regeneration in our model through changes in collagen organization; cell shape and orientation; and increase in mechanical properties over those of the untreated controls. Clinical Relevance: Cell therapy has been shown to be effective in treating tendon injuries, especially in equines. We have recently isolated a mesenchymal cell population from equine umbilical cords that is analogous to a well-characterized HUCPVC population. Our results indicate that HUCPVCs are a putative cell source for treating tendon injuries; and this model could explain the benefits of using analogous cells in equines.

Umbilical Cord Perivascular Cells: A Mesenchymal Cell Source for Treatment of Tendon Injuries