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A growing body of evidence suggests that regular ‘ecstasy’ (3, 4-methylenedioxymethamphetamine; MDMA) use causes lasting changes to central serotonergic functioning in humans, including in the occipital lobe. Brown, Edwards, et al. [1] proposed that MDMA-related serotonergic changes in the occipital lobe may reduce lateral inhibition between occipital neurons involved in low level visual perception, resulting in broadening the tuning bandwidths of those neurons.

The Role of Serotonin in Low Level Visual Processes, as Revealed by Using an “Ecstasy” (MDMA)-Based Research Model