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Oversulfated chrondroitin sulfate (OSCS) was recently identified as a contaminant of heparin and was associ- ated with serious adverse events in patients treated with heparin. Because heparin is a common component of blood col- lection tubes, we tested the effect of OSCS on the laboratory analysis of plasma. Blood from healthy volunteers (N=50) was collected into tubes containing various mixtures of heparin and OSCS. Samples were inspected for microclots and were analyzed for a panel of 28 routine laboratory tests. No microclots were observed in tubes that contained only heparin but were detected in 18%, 88% and 76% of plasma samples containing 5%, 15%, 20% OSCS (%weight relative to hepa- rin), respectively. OSCS at the highest dose (20%) caused a systematic bias for the following 6 tests: Lactate Dehydro- genase: 18% (12% to 24%); Triiodothyronine: -5.7% (-8.1% to -3.3%); Potassium: -2.8% (-4.2% to -1.4%); Total Protein: 2.5% (1.4% to 3.6%); Chloride: -1.4% (-1.8% to -1.0%) and Uric Acid: 1% (0.5% to 1.4%). In summary, OSCS contami- nation of heparin was found to potentially affect the anticoagulation of plasma and the analytical performance of several routine clinical laboratory tests.

Effect of Heparin Contaminated with Oversulfated Chondroitin Sulfate on the Collection and Analysis of Plasma~!2009-10-12~!2010-02-04~!2010-03-25~!