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THC is the primary psychoactive compound of Cannabis sativa and while the human abuse potential of THC is well recognised, knowledge of its reinforcing and dependence-producing effects is limited. In addition to euphoric proper- ties, cannabinoids are known to attenuate learning and memory in both humans and animals but the underlying mecha- nism is unclear. The present study investigated the effects of chronic THC treatment on CB1 receptor-mediated reward. In addition, DA and 5HT and their metabolites DOPAC, HVA and 5HIAA were measured in the striatum and hippocampus. Chronic THC (0.5, 2.0 and 5.0mg/Kg ip, 21 days) had no significant effect on conditioned place preference while DA content of the striatum was increased by chronic THC in a dose-dependant manner.

Chronic Delta-9-tetrahydrocannabinol Induces Monoamine Release but Not Conditioned Place Preference