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To examine whether Coxiella burnetii (C. burnetii) is involved in chronic fatigue syndrome (CFS), we administered tetracycline antibiotics to subjects with CFS, and followed changes in clinical symptoms, PCR findings, and C. burnetii antibody titers.

Treatment of Chronic Fatigue Syndrome with Antibiotics: Pilot Study Assessing the Involvement of Coxiella burnetii Infection