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To clarify the effectiveness of methylprednisolone pulse therapy on crescentic glomerulonephritis (CresGN), data of 46 patients was retrospectively studied. According to the slope of reciprocals of serum creatinine (s-Cr) the patients were divided into acute and insidious types, and each type was further divided into pulse (P) and conventional (C) therapy groups. In group C, s-Cr improved more frequently in the acute type (8/10) than in the insidious type (1/9, p&lt;0.05), and the renal survival rate was somewhat higher in the former (p=0.09). In the acute type there was no difference in the improvement rate of s-Cr between the two therapy groups, whereas in the insidious type, the improvement rate was higher in group P (9/15) than in group C (1/9, p&lt;0.05) and the renal survival rate was higher in the former (p&lt;0.01). These results suggest that methylprednisolone pulse therapy may be highly effective for the insidious type of CresGN.

Methylprednisolone Pulse Therapy in Two Clinical Types of Crescentic Glomerulonephritis.