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A 50-year-old man with Churg-Strauss syndrome showed granulocytes (GNLs) which generated more superoxide anion (O2-) than GNLs from healthy subjects following in vitro stimulation with C5a or C3a. Production of O2- subsided as the clinical symptoms improved with steroid treatment. A hyperresponsiveness of GNLs may be involved in this disorder.

Hyperresponsiveness of Granulocytes to Anaphylatoxins, C5a and C3a, in Churg-Strauss Syndrome.