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We report a rare case of complete remission for 32 months with continuous treatment with all-trans retinoic acid (ATRA) alone in a patient with acute promyelocytic leukemia which developed as a second malignancy after the treatment of osteosarcoma after failure of conventional chemotherapy. The adverse effects of ATRA were apparently tolerable.

internal medicine

Successful Continuous Treatment with All-Trans Retinoic Acid for Acute Promyelocytic Leukemia; Secondary Malignancy after the Treatment of Osteosarcoma.